To be eligible to play Wheelchair Rugby, individuals must have a disability which affects all four limbs. Most players have spinal cord injuries with full or partial paralysis of the legs and partial paralysis of the arms. Other disability groups who play include cerebral palsy, muscular dystrophy, amputations, polio, and other neurological conditions. Men and women compete on the same teams and in the same competitions.
Players are assigned a sport classification based on their level of disability; teams must field players with a mix of classification values, allowing players with different functional abilities to compete together.